According to Chris Avellone, Senior Designer for Obsidian Games, the Mojave Wasteland is so big it's trippy, and that trippiness causes bugs.
In an interview with ComputerAndVideoGames.com, Avellone ranted like a dirty hippie: "It's kind of like the bugs of the real world - the sheer expanse of what you're dealing with causes problems. Everything's copastetic, now if you'll excuse me, I have a hacky-sac to play with. Peace bro." Avellone made no mention about how the Gamebryo engine made things worse, a smart move considering Bethesda keeps coming back to it like a crack addled whore.
He did however point out that even the team of 300 testers used to bug test the game couldn't spot the all the bugs, a statement that is made true only when you realize that there are so many game braking bugs, that NO ONE TESTED THE GAME AND HE'S LYING.